Our experience is that the new chain will encounter twist more at the locker end than used chain. We start to notice that twist once about 120 feet or more of the chain is out. And no, its not due to spinning around at anchor, it is due to the way that the new chain sits and somehow works up onto itself in the locker. Physically untwisting the chain will work it out [heavy job though].
The coning that occurs when weighing anchor is just the same with new as well as old. So, on recap, our finding is that the only difference between new and old chain is that twist. Hope that helps.